Where do totipotent cells appear during development?
One of the most interesting details for me was the timing of totipotent cells. According to the article, they occur during the earliest stages of embryonic development, beginning with the fertilized egg and its first divisions. Their unique developmental potential allows them to contribute to all the cell types and supporting structures needed for development. Pluripotent cells appear later, including in the inner cell mass of the blastocyst, which is why their developmental capabilities are somewhat more limited https://ways2well.com/blog/how-pluripotent-cells-differ-from-totipotent-cells-and-why-it-matters
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